Delivering drugs with better effectiveness, higher quality and lowee cost

CXCR4/CXCL12 Axis

CXCR4 is the only functional chemokine receptor expressed on hematopoietic stem cells (HSC)

CXCL12 promotes:

CXCR4+ cell motility, stimulating cytoskeletal rearrangements (leading edge formation)

CXCR4+ cell homing to CXCL12-rich tissue by upregulating integrins and matrix metalloproteinases(MMPs)

CXCR4 / CXCL12 axis promotes tumor cell proliferation, angiogenesis, and evades the monitoring of the immune system for diffusion.

CXCR4 overexpression has been detected in > 48 cancer types.

CXCR4 / CXCL12 Antagonists in Cancer

Disrupt tumor-associated stromal interactions that confer tumor cell survival and drug resistance

Block paracrine growth and survival signals through activation of the CXCR4 / CXCL12 axis

Block CXCL12-mediated recruitment of proangiog enic, bone marrow-derived progenitor cells

Block tumor cell metastasis to distant CXCL12-rich stromal niches

Mobilize tumor cells from CXCL12-rich tissue to increase chemotherapeutic accessibility